Chronic Granulomatous (gran-u-LOM-uh-tus) Disease (CGD) is an inherited disorder that occurs when a type of white blood cell (phagocyte) that usually helps your body fight infections doesn't work properly. As a result, the phagocytes can't protect your body from bacterial and fungal infections.
Chronic Granulomatous Disease (CGD) is an inherited disorder that affects the immune system. Chronic Granulomatous Disease may develop infections in their lungs, skin, lymph nodes, liver, stomach and intestines, or other areas. They may also develop clusters of white blood cells in infected areas. Most people are diagnosed with CGD during childhood, but some people may not be diagnosed until adulthood.
The most common form of Chronic Granulomatous Disease (CGD) is X-linked. It’s passed down from the mother because she carries a faulty X chromosome. This means she is a carrier of Chronic Granulomatous Disease (CGD). Usually only males get X-linked CGD. A male born to a carrier mother has a 50% chance of having CGD.
Signs and Symptoms Associated with Infections include :
Swelling and Redness in your mouth
Chest Pain when Inhaling or Exhaling
Swollen and Sore Lymph Glands
A Persistent Runny Nose
Children may Grow Slowly
Treatments for Chronic Granulomatous Disease (CGD) includes :
Infection Management : Your doctor will work to prevent bacterial and fungal infections before they occur. Treatment may include continuous antibiotic therapy, such as trimethoprim and sulfamethoxazole combination (Bactrim, Sulfatrim Pediatric) to protect against bacterial infections, and itraconazole (Sporanox, Tolsura) to prevent fungal infection. Additional antibiotics or antifungal medications may be necessary should infection occur.
Interferon - Gamma : You may have interferon-gamma injections periodically, which may help boost cells in your immune system to fight infections.
Stem Cell Transplantation : In some cases, a stem cell transplant can provide a cure for CGD. Deciding to treat with stem cell transplantation depends on a number of factors, including prognosis, donor availability and personal preference.